Stimuli-responsive magnetic nanoparticles for tumor-targeted bimodal imaging and photodynamic/hyperthermia combination therapyElectronic supplementary information (ESI) available. See DOI: 10.1039/c6nr02273a

• Main Authors: Kim, Kyoung Sub, Kim, Jiyoung, Lee, Joo Young, Matsuda, Shofu, Hideshima, Sho, Mori, Yasurou, Osaka, Tetsuya, Na, Kun
• Format: Journal Article
• Published: 02.06.2016
• ISSN: 2040-3364; 2040-3372
• DOI: 10.1039/c6nr02273a

Despite magnetic nanoparticles having shown great potential in cancer treatment, tremendous challenges related to diagnostic sensitivity and treatment efficacy for clinical application remain. Herein, we designed optimized multifunctional magnetite nanoparticles (AHP@MNPs), composed of Fe 3 O 4 nanoparticles and photosensitizer conjugated hyaluronic acid (AHP), to achieve enhanced tumor diagnosis and therapy. Fe 3 O 4 nanoparticles (MNPs) were synthesized by a facile hydrolysis method. MNPs have higher biocompatibility, controllable particle sizes, and desirable magnetic properties. The fabricated AHP@MNPs have enhanced water solubility (average size: 108.13 ± 1.08 nm), heat generation properties, and singlet oxygen generation properties upon magnetic and laser irradiation. The AHP@MNPs can target tumors via CD44 receptor-mediated endocytosis, which have enhanced tumor therapeutic effects through photodynamic/hyperthermia-combined treatment without any drugs. We successfully detected tumors implanted in mice via magnetic resonance imaging and optical imaging. Furthermore, we demonstrated the photodynamic/hyperthermia-combined therapeutic efficacy of AHP@MNPs with synergistically enhanced efficacy against cancer. We demonstrated the photodynamic/hyperthermia-combined therapeutic efficacy of stimuli-responsive magnetic nanoparticle with synergistically enhanced efficacy against cancer.