Polyphenolic carbosilane dendrimers as anticancer agents against prostate cancerElectronic supplementary information (ESI) available. See DOI: 10.1039/c6nj02545e

Carbosilane dendrimers containing vanillin on the surface have been prepared with the purpose of combining the unique antioxidant and anticancer properties of polyphenols and dendrimers. These new compounds exhibit antioxidant potency as free-radical scavengers, as determined by DPPH and ABTS. Remar...

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Main Authors Mencia, Gabriel, del Olmo, Natalia Sanz, Muñoz-Moreno, Laura, Maroto-Diaz, Marta, Gomez, Rafael, Ortega, Paula, José Carmena, M a, Javier de la Mata, F
Format Journal Article
LanguageEnglish
Published 28.11.2016
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Summary:Carbosilane dendrimers containing vanillin on the surface have been prepared with the purpose of combining the unique antioxidant and anticancer properties of polyphenols and dendrimers. These new compounds exhibit antioxidant potency as free-radical scavengers, as determined by DPPH and ABTS. Remarkably, all synthesized dendrimers exhibit improved antioxidant efficacy compared to vanillin. Anticancer activity has been studied against HeLa cervical and PC3 human prostate cancer cell lines. Proliferation, cell cycle, adhesion and migration in human prostate tumor cells have been studied. Data revealed a general trend indicating that polyphenolic dendrimers are more cytotoxic than their monopolyphenolic counterparts in both cancer cell lines. Polyphenolic carbosilane dendrimers improved the antioxidant and anticancer properties of free vanillin.
Bibliography:10.1039/c6nj02545e
Electronic supplementary information (ESI) available. See DOI
ISSN:1144-0546
1369-9261
DOI:10.1039/c6nj02545e