Novel oxazine and oxazone dyes: aggregation behavior and physicochemical propertiesElectronic supplementary information (ESI) available. See DOI: 10.1039/c6nj02053d

This research evaluated the synthesis and suitability of synthetic and commercial photosensitizers for use as potential photosensitizers in photodynamic therapy and photodynamic antimicrobial chemotherapy. Spectroscopic properties, experimental aggregation behavior in ethanol, N , N -dimethylformami...

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Bibliographic Details
Main Authors Urrutia, María N, Ortiz, Cristina S
Format Journal Article
LanguageEnglish
Published 28.11.2016
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Summary:This research evaluated the synthesis and suitability of synthetic and commercial photosensitizers for use as potential photosensitizers in photodynamic therapy and photodynamic antimicrobial chemotherapy. Spectroscopic properties, experimental aggregation behavior in ethanol, N , N -dimethylformamide, water and water : polyethylene glycol 400, computational details, the ability to generate singlet oxygen, log  P HPLC and theoretical log  P were determined. All the compounds evaluated formed aggregates in different media. Novel brominated tested compounds exhibited higher lipophilicity and generation of singlet oxygen in comparison with the corresponding starting reagent. The studies showed that the tested oxazine and oxazone dyes satisfy the conditions of a potential drug in terms of physicochemical and photochemical properties. Novel compounds exhibited good properties in comparison with the corresponding starting reagent and satisfy the conditions of a potential drug.
Bibliography:10.1039/c6nj02053d
Electronic supplementary information (ESI) available. See DOI
ISSN:1144-0546
1369-9261
DOI:10.1039/c6nj02053d