Homochiral crystal generation via sequential dehydration and Viedma ripeningElectronic supplementary information (ESI) available: Detailed synthetic procedure, characterization as well as crystallographic data are described in the ESI. CCDC 1443506-1443508. The resubmission of the CIF file of 2 was performed due to the incomplete entry in the CSD 5.36 database. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ce00119j

• Main Authors: Sivakumar, Reajean, Askari, Mohammad S, Woo, Simon, Madwar, Carolin, Ottenwaelder, Xavier, Bohle, D. Scott, Cuccia, Louis A
• Format: Journal Article
• Published: 07.06.2016
• ISSN: 1466-8033
• DOI: 10.1039/c6ce00119j

1,2-Bis( N -benzoyl- N -methylamino)benzene ( 2 ) forms centrosymmetric hydrate crystals (2· x H 2 O) and non-centrosymmetric anhydrous crystals. Dehydration of this hydrate (30 min at 140 °C) resulted in the formation of chiral crystals ( i.e. a physical racemate of the conglomerate crystals) as verified using solid-state circular dichroism and powder X-ray diffraction. Subsequent attrition-enhanced deracemization, also known as Viedma ripening, was used to obtain homochiral crystals of 2 within 5 h. Asymmetric amplification of conglomerate crystals formed via the dehydration of initially achiral crystals was achieved using Viedma ripening.