Catalyst-free N-methylation of amines using CO2Electronic supplementary information (ESI) available. See DOI: 10.1039/c6cc09072a

Recently, utilizing CO 2 as a methylation reagent to construct functional chemicals has attracted significant attention. However, the conversion of CO 2 is still a challenge due to its inherent inertness. In this study, we have developed a catalyst-free N -methylation of amines to prepare numerous m...

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Bibliographic Details
Main Authors Niu, Huiying, Lu, Lijun, Shi, Renyi, Chiang, Chien-Wei, Lei, Aiwen
Format Journal Article
LanguageEnglish
Published 17.01.2017
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Summary:Recently, utilizing CO 2 as a methylation reagent to construct functional chemicals has attracted significant attention. However, the conversion of CO 2 is still a challenge due to its inherent inertness. In this study, we have developed a catalyst-free N -methylation of amines to prepare numerous methylamines using CO 2 as a methyl source. By utilizing 2 eq. PhSiH 3 as the reductant, amines could undergo N -methylation under 1 atm of CO 2 in DMF at 90 °C. Aliphatic and aromatic amines were compatible, generating the desired products in up to 95% yield. In this study, we have developed a catalyst-free N -methylation of amines to prepare numerous methylamines using CO 2 as a methyl source, utilizing 2 eq. PhSiH 3 as the reductant.
Bibliography:10.1039/c6cc09072a
Electronic supplementary information (ESI) available. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc09072a