A CoII complex for 19F MRI-based detection of reactive oxygen speciesElectronic supplementary information (ESI) available: Experimental details, NMR, electrochemistry, electronic spectra, and IR spectra. See DOI: 10.1039/c6cc08207f
A fluorinated, air-stable cobalt( ii ) complex serves as a turn-on 19 F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H 2 O 2 . Upon oxidation with H 2 O 2 , the complex converts from paramagnetic high spin Co II to diamagnetic low spin Co III resulting in a chemical...
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| Main Authors | , , , , , |
|---|---|
| Format | Journal Article |
| Language | English |
| Published |
24.11.2016
|
| Online Access | Get full text |
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| Summary: | A fluorinated, air-stable cobalt(
ii
) complex serves as a turn-on
19
F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H
2
O
2
. Upon oxidation with H
2
O
2
, the complex converts from paramagnetic high spin Co
II
to diamagnetic low spin Co
III
resulting in a chemical shift change and enhancement in
19
F NMR signal. Further, the oxidation can be reversed in the presence of reductant Na
2
S
2
O
4
. The turn-on response is demonstrated by
19
F MRI, characterized by a ∼2-3 fold enhancement in signal.
A fluorinated, cobalt(
ii
)-based
19
F MRI imaging agent switches from a paramagnetic high spin Co
II
state to a diamagnetic low spin Co
III
state following oxidation by H
2
O
2
and other reactive oxygen species, resulting in a turn-on response
via
both
19
F NMR and MRI. |
|---|---|
| Bibliography: | Electronic supplementary information (ESI) available: Experimental details, NMR, electrochemistry, electronic spectra, and IR spectra. See DOI 10.1039/c6cc08207f |
| ISSN: | 1359-7345 1364-548X |
| DOI: | 10.1039/c6cc08207f |