Observation of intracellular interactions between DNA origami and lysosomes by the fluorescence localization methodElectronic supplementary information (ESI) available. See DOI: 10.1039/c6cc00484a

We obtained the fluorescence localization images of tube DNA origami nanostructures in NIH 3T3 cells for the first time. The fluorescence localization images of tube DNA origami nanostructures and TIRF images of lysosomes were combined and they revealed the detailed interactions between the two stru...

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Bibliographic Details
Main Authors Fu, Meifang, Dai, Luru, Jiang, Qiao, Tang, Yunqing, Zhang, Xiaoming, Ding, Baoquan, Li, Junbai
Format Journal Article
Published 14.07.2016
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Summary:We obtained the fluorescence localization images of tube DNA origami nanostructures in NIH 3T3 cells for the first time. The fluorescence localization images of tube DNA origami nanostructures and TIRF images of lysosomes were combined and they revealed the detailed interactions between the two structures. Quantitative analysis illustrated that the tube origami can be captured as well as degraded by lysosomes with time. The combined image (b) of the fluorescence localization image of DNA origami and the TIRF image of lysosomes illustrates detailed interactions between them.
Bibliography:10.1039/c6cc00484a
Electronic supplementary information (ESI) available. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc00484a