Micrometer-sized network structure of novel DNA-lipid conjugates induced by heat stimulationElectronic supplementary information (ESI) available: Phase contrast micrographs and a movie of Mg2+-containing buffer solutions of a series of DNA lipid conjugates. See DOI: 10.1039/c5sm01456e

• Main Authors: Takahashi, K, Matsuo, M, Banno, T, Toyota, T
• Format: Journal Article
• Language: English
• Published: 26.08.2015
• ISSN: 1744-683X; 1744-6848
• DOI: 10.1039/c5sm01456e

We have developed a novel lipid-bearing DNA that forms hairpin modules, including a single RNA monomer; this can be used to create micrometer-sized structures from nanometer-sized building blocks during breakage at the RNA site. In the presence of divalent metal ions and heat stimulation, we observed transition of the self-assembly, which results in the formation of a three-dimensional network structure. To our knowledge, this is also the first report of heat-induced micrometer-sized molecular self-assembly of molecules that carry biological information. We have developed a novel lipid-bearing DNA that forms hairpin modules, including a single RNA monomer; this can be used to create micrometer-sized structures from nanometer-sized building blocks during breakage at the RNA site.