Optical control of neuronal firing photoinduced electron transfer in donor-acceptor conjugates

A series of porphyrinfullerene linked molecules has been synthesized to evaluate the effects of substituents and molecular structures on their charge-separation yield and the lifetime of a final charge-separated state in various hydrophilic environments. The selected high-performance molecule effect...

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Published inChemical science (Cambridge) Vol. 7; no. 5; pp. 3331 - 3337
Main Authors Takano, Yuta, Numata, Tomohiro, Fujishima, Kazuto, Miyake, Kazuaki, Nakao, Kazuya, Grove, Wesley David, Inoue, Ryuji, Kengaku, Mineko, Sakaki, Shigeyoshi, Mori, Yasuo, Murakami, Tatsuya, Imahori, Hiroshi
Format Journal Article
Published 25.04.2016
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Summary:A series of porphyrinfullerene linked molecules has been synthesized to evaluate the effects of substituents and molecular structures on their charge-separation yield and the lifetime of a final charge-separated state in various hydrophilic environments. The selected high-performance molecule effectively achieved depolarization in a plasma cell membrane by visible light as well as two-photon excitation using a near-infrared light laser. Moreover, it was revealed that the depolarization can trigger neuronal firing in rat hippocampal neurons, demonstrating the potential and versatility for controlling cell functions using light. A rationally designed donoracceptor conjugate efficiently generates a photoinduced charge-separated state in a cellular environment, achieving photoinduction of neuronal firing.
Bibliography:Electronic supplementary information (ESI) available: Experimental procedures and spectroscopic data for all new compounds, supplementary characterizations, and optimized structures by theoretical calculations. See DOI
10.1039/c5sc04135j
ISSN:2041-6520
2041-6539
DOI:10.1039/c5sc04135j