Enantioselectivity switch in copper-catalyzed conjugate addition reactions under the influence of a chiral N-heterocyclic carbene-silver complexElectronic supplementary information (ESI) available: Experimental details, Scheme S1, S2, data for Fig. 1 and spectral data. See DOI: 10.1039/c5ra25926f

The asymmetric 1,4-addition of Et 2 Zn to 2-cyclohexen-1-one using a Cu( i ) salt/N-heterocyclic carbene (NHC)-Ag complex catalytic system afforded optically active 3-ethylcyclohexanone. The reversal of enantioselectivity using the same catalytic system was achieved by changing the order of the addi...

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Main Authors Matsumoto, Keitaro, Nakano, Yuki, Shibata, Naoatsu, Sakaguchi, Satoshi
Format Journal Article
Published 19.01.2016
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Summary:The asymmetric 1,4-addition of Et 2 Zn to 2-cyclohexen-1-one using a Cu( i ) salt/N-heterocyclic carbene (NHC)-Ag complex catalytic system afforded optically active 3-ethylcyclohexanone. The reversal of enantioselectivity using the same catalytic system was achieved by changing the order of the addition of substrates. The reversal of enantioselectivity using the same catalytic system was achieved simply by changing the order of the addition of substrates.
Bibliography:Electronic supplementary information (ESI) available: Experimental details, Scheme S1, S2, data for Fig. 1 and spectral data. See DOI
10.1039/c5ra25926f
ISSN:2046-2069
DOI:10.1039/c5ra25926f