Parallel synthesis and biological evolution of quinic acid derivatives as immuno-suppressing agents against T-cell receptorsElectronic supplementary information (ESI) available. CCDC 1058469. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5ra06095h

• Main Authors: Huang, Chih-Yu, Chen, Li-Hsun, Huang, Hsuan-Yu, Kao, Feng-Sheng, Lee, Yun-Ta, Selvaraju, Manikandan, Sun, Chung-Ming, Chen, Hueih-Min
• Format: Journal Article
• Language: English
• Published: 08.06.2015
• ISSN: 2046-2069
• DOI: 10.1039/c5ra06095h

A simple protocol for the synthesis of quinic acid derivatives was established and their biological evolution against T-cells is studied. Results showed that one of the derivatives, Cyn-1324, has low toxicity on T-cells and a high effect on reducing Signal 2 of T-cell immune responses. In vitro binding measurements of atomic force spectroscopy further indicated that the blocking effect of Cyn-1324 between CD28 and CD80 was about 31 ± 4%. In vivo animal tests also confirmed that Cyn-1324 can reduce the allergic responses from ovalbumin-induced mice with little toxicity. Based on these observations, Cyn-1324 can be a mild immuno-suppressive candidate for future drug development. A parallel synthesis of quinic acid derivatives is explored and their biological evolution against T-cells is studied.