A new pathway towards polymer modified cellulose nanocrystals via a "grafting onto" process for drug deliveryElectronic supplementary information (ESI) available: Materials, synthesis and characterization of CNC-N3, propargyl-PEEPn, CNC-g-PEEPn, the 1H NMR spectrum, GPC results, elementary data and zeta-potential results. See DOI: 10.1039/c5py00466g

Poly(ethyl ethylene phosphate) (PEEP) modified cellulose nanocrystals (CNCs) (CNC- g -PEEP) were synthesized through a "grafting onto" process, in which a combination of ring-opening polymerization (ROP) and Cu( i )-catalyzed azide-alkyne cycloaddition (CuAAC) "click" chemistry w...

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Bibliographic Details
Main Authors Wang, Hairong, He, Jinlin, Zhang, Mingzu, Tam, Kam Chiu, Ni, Peihong
Format Journal Article
LanguageEnglish
Published 02.06.2015
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Summary:Poly(ethyl ethylene phosphate) (PEEP) modified cellulose nanocrystals (CNCs) (CNC- g -PEEP) were synthesized through a "grafting onto" process, in which a combination of ring-opening polymerization (ROP) and Cu( i )-catalyzed azide-alkyne cycloaddition (CuAAC) "click" chemistry was utilized. The resulting suspension of negatively-charged CNC- g -PEEP nanocrystals could be used to encapsulate doxorubicin (DOX) by electrostatic interactions and release the drug in the tumor cell environment. Polyphosphoester modified cellulose nanocrystals (CNCs) (CNC- g -PEEP) have been synthesized through a "grafting onto" process and used for pH-triggered delivery of doxorubicin.
Bibliography:the
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PEEP
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CNC-
10.1039/c5py00466g
H NMR spectrum, GPC results, elementary data and zeta-potential results. See DOI
Electronic supplementary information (ESI) available: Materials, synthesis and characterization of CNC-N
n
propargyl-PEEP
ISSN:1759-9954
1759-9962
DOI:10.1039/c5py00466g