Graphene oxide complex as a pH-sensitive antitumor drugElectronic supplementary information (ESI) available: AFM images of GCS and GO, High resolution XPS O 1s spectra of GO and GCS, TEM images of HeLa cells incubated with GCS. See DOI: 10.1039/c5py00047e

A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The res...

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Main Authors Cheng, Rumei, Zou, Ruitao, Ou, Shengju, Guo, Rui, Yan, Ruiying, Shi, Haiyan, Yu, Shanshan, Li, Xiaojian, Bu, Yexu, Lin, Mimi, Liu, Yong, Dai, Liming
Format Journal Article
LanguageEnglish
Published 17.03.2015
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Summary:A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs. A chitosan-xanthone-GO nanocomposite as a pH-sensitive nanocarrier for controlled release of the antitumor drug.
Bibliography:10.1039/c5py00047e
Electronic supplementary information (ESI) available: AFM images of GCS and GO, High resolution XPS O 1s spectra of GO and GCS, TEM images of HeLa cells incubated with GCS. See DOI
ISSN:1759-9954
1759-9962
DOI:10.1039/c5py00047e