Graphene oxide complex as a pH-sensitive antitumor drugElectronic supplementary information (ESI) available: AFM images of GCS and GO, High resolution XPS O 1s spectra of GO and GCS, TEM images of HeLa cells incubated with GCS. See DOI: 10.1039/c5py00047e
A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The res...
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Main Authors | , , , , , , , , , , , |
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Format | Journal Article |
Language | English |
Published |
17.03.2015
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Online Access | Get full text |
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Summary: | A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs.
A chitosan-xanthone-GO nanocomposite as a pH-sensitive nanocarrier for controlled release of the antitumor drug. |
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Bibliography: | 10.1039/c5py00047e Electronic supplementary information (ESI) available: AFM images of GCS and GO, High resolution XPS O 1s spectra of GO and GCS, TEM images of HeLa cells incubated with GCS. See DOI |
ISSN: | 1759-9954 1759-9962 |
DOI: | 10.1039/c5py00047e |