Quantitative chirality sensing of amines and amino alcohols via Schiff base formation with a stereodynamic UV/CD probeElectronic supplementary information (ESI) available. CCDC 1440658-1440660. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5ob02529j

A stereodynamic chemosensor that can be used for simultaneous determination of the absolute configuration, enantiomeric composition and total concentration of chiral amines and amino alcohols based on two fast optical measurements was prepared and tested. The free sensor is CD-silent and produces ch...

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Bibliographic Details
Main Authors De los Santos, Zeus A, Ding, Ransheng, Wolf, Christian
Format Journal Article
Published 02.02.2016
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Summary:A stereodynamic chemosensor that can be used for simultaneous determination of the absolute configuration, enantiomeric composition and total concentration of chiral amines and amino alcohols based on two fast optical measurements was prepared and tested. The free sensor is CD-silent and produces characteristic blue-shifted UV and CD signals upon substrate binding via Schiff base formation. The potential in high-throughput screening applications and for rational sensor developments are discussed. A readily available probe is used for quantitative sensing of the concentration and ee of chiral amines and amino alcohols.
Bibliography:Electronic supplementary information (ESI) available. CCDC
For ESI and crystallographic data in CIF or other electronic format see DOI
1440658-1440660
10.1039/c5ob02529j
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob02529j