Metal-free methylation of a pyridine N-oxide C-H bond by using peroxidesElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ob01900a

Metal-free methylation of a pyridine N -oxide C-H bond was developed using peroxide as a methyl reagent under neat conditions. Pyridine N -oxide derivatives with various groups ( e.g. , Cl, NO 2 , and OCH 3 ) were all suitable substrates, and the desired products were obtained in moderate to excelle...

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Main Authors Li, Gang, Yang, Suling, Lv, Bingjie, Han, Qingqing, Ma, Xingxing, Sun, Kai, Wang, Zhiyong, Zhao, Feng, Lv, Yunhe, Wu, Hankui
Format Journal Article
LanguageEnglish
Published 17.11.2015
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Summary:Metal-free methylation of a pyridine N -oxide C-H bond was developed using peroxide as a methyl reagent under neat conditions. Pyridine N -oxide derivatives with various groups ( e.g. , Cl, NO 2 , and OCH 3 ) were all suitable substrates, and the desired products were obtained in moderate to excellent yields under standard conditions. Moreover, the methylation can be performed with a good yield on the gram-scale experiment. Tentative mechanistic studies show that the methylation is a classical radical process. Metal-free methylation of a pyridine N -oxide C-H bond was developed using peroxide as a methyl reagent under neat conditions. Pyridine N -oxide derivatives with various groups ( e.g. , Cl, NO 2 , and OCH 3 ) were all suitable substrates.
Bibliography:10.1039/c5ob01900a
Electronic supplementary information (ESI) available. See DOI
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob01900a