An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrinElectronic supplementary information (ESI) available. CCDC 1054454. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5ob01125f

• Main Authors: Liao, Fu-Min, Liu, Yun-Lin, Yu, Jin-Sheng, Zhou, Feng, Zhou, Jian
• Format: Journal Article
• Language: English
• Published: 11.08.2015

We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This method is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B. We report an efficient...