An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrinElectronic supplementary information (ESI) available. CCDC 1054454. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5ob01125f

We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This method is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B. We report an efficient...

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Bibliographic Details
Main Authors Liao, Fu-Min, Liu, Yun-Lin, Yu, Jin-Sheng, Zhou, Feng, Zhou, Jian
Format Journal Article
LanguageEnglish
Published 11.08.2015
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Summary:We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This method is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B. We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This represents the first modification of tryptanthrin by a fluoroalkyl group, which is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B.
Bibliography:Electronic supplementary information (ESI) available. CCDC
For ESI and crystallographic data in CIF or other electronic format see DOI
1054454
10.1039/c5ob01125f
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob01125f