3-Nitro-2-pyridinesulfenyl-mediated solid-phase disulfide ligation in the synthesis of disulfide bond-containing cyclic peptidesElectronic supplementary information (ESI) available: Detailed experimental procedures, characterization, and chromatographic data. See DOI: 10.1039/c5ob00030k

A new solid-phase disulfide ligation method is developed to prepare a disulfide peptide from two types of Cys-containing peptide fragments with minimum purification steps. In combination with the subsequent intramolecular amide bond formation, a cyclic nonapeptide, oxytocin, was efficiently synthesi...

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Main Authors Taguchi, Akihiro, Fukumoto, Kentarou, Asahina, Yuya, Kajiyama, Akihiro, Shimura, Shunsuke, Hamada, Keisuke, Takayama, Kentaro, Yakushiji, Fumika, Hojo, Hironobu, Hayashi, Yoshio
Format Journal Article
LanguageEnglish
Published 04.03.2015
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Summary:A new solid-phase disulfide ligation method is developed to prepare a disulfide peptide from two types of Cys-containing peptide fragments with minimum purification steps. In combination with the subsequent intramolecular amide bond formation, a cyclic nonapeptide, oxytocin, was efficiently synthesized as a fundamental model for more complex cyclic peptides. A new solid-phase disulfide ligation method is developed to prepare a disulfide peptide from two types of Cys-containing peptide fragments with minimum purification steps.
Bibliography:Electronic supplementary information (ESI) available: Detailed experimental procedures, characterization, and chromatographic data. See DOI
10.1039/c5ob00030k
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob00030k