Discovery of a potent and highly fluorescent sirtuin inhibitorElectronic supplementary information (ESI) available: Compound characterization data, supplementary biological data, additional photochemical measurements and molecular docking analyses. See DOI: 10.1039/c5md00307e

In search for potent sirtuin inhibitors, a series of diversified 1,2-disubstituted benzimidazole analogues were synthesized using a one-pot method. The most potent compound in the series ( BZD9L1 ) was discovered to show high autofluorescence which can be utilized to predict its localization in cell...

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Bibliographic Details
Main Authors Yoon, Y. K, Ali, M. A, Wei, A. C, Choon, T. S, Shirazi, A. N, Parang, K
Format Journal Article
LanguageEnglish
Published 08.10.2015
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Summary:In search for potent sirtuin inhibitors, a series of diversified 1,2-disubstituted benzimidazole analogues were synthesized using a one-pot method. The most potent compound in the series ( BZD9L1 ) was discovered to show high autofluorescence which can be utilized to predict its localization in cells. More importantly, BZD9L1 displayed strong antiproliferative effects against a panel of cancer cells tested. Molecular docking studies also help to explain the observed structure-activity relationship. Highly fluorescent sirtuin inhibitor was discovered to possess growth inhibitory effect against multiple cancer cell lines.
Bibliography:10.1039/c5md00307e
Electronic supplementary information (ESI) available: Compound characterization data, supplementary biological data, additional photochemical measurements and molecular docking analyses. See DOI
ISSN:2040-2503
2040-2511
DOI:10.1039/c5md00307e