Quantifying transient interactions between amide groups and the guanidinium cationElectronic supplementary information (ESI) available. See DOI: 10.1039/c5cp04619j

We study the interaction of the guanidinium cation, a widely used protein denaturant, with amide groups, the common structural motif of proteins. Our results provide evidence for direct contact between guanidinium and ∼2 amide groups, but the interaction is transient and weaker than for other cation...

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Bibliographic Details
Main Authors Balos, V, Bonn, M, Hunger, J
Format Journal Article
LanguageEnglish
Published 28.10.2015
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Summary:We study the interaction of the guanidinium cation, a widely used protein denaturant, with amide groups, the common structural motif of proteins. Our results provide evidence for direct contact between guanidinium and ∼2 amide groups, but the interaction is transient and weaker than for other cations with high charge-density. The guanidinium cation interacts with amide groups, the interaction strength is - compared to other cations - only intermediate.
Bibliography:Electronic supplementary information (ESI) available. See DOI
10.1039/c5cp04619j
ISSN:1463-9076
1463-9084
DOI:10.1039/c5cp04619j