Small molecule diselenide additives for in vitro oxidative protein foldingElectronic supplementary information (ESI) available: Details of synthetic procedures for diselenides 1-3 and full characterizations. See DOI: 10.1039/c5cc10451c
The in vitro oxidative folding of disulfide-rich proteins can be challenging. Here we show a new class of small molecule diselenides, which can be easily prepared from inexpensive starting materials, used to enhance oxidative protein folding. These compounds were tested on a model protein, bovine pa...
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| Main Authors | , |
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| Format | Journal Article |
| Published |
16.02.2016
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| Online Access | Get full text |
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| Summary: | The
in vitro
oxidative folding of disulfide-rich proteins can be challenging. Here we show a new class of small molecule diselenides, which can be easily prepared from inexpensive starting materials, used to enhance oxidative protein folding. These compounds were tested on a model protein, bovine pancreatic trypsin inhibitor. Two of the tested diselenides showed considerable improvement over glutathione and were on par with the previously described selenoglutathione.
Small molecule diselenides were prepared and found to enhance the
in vitro
oxidative folding of disulfide-rich protein. |
|---|---|
| Bibliography: | 10.1039/c5cc10451c and full characterizations. See DOI 1-3 Electronic supplementary information (ESI) available: Details of synthetic procedures for diselenides |
| ISSN: | 1359-7345 1364-548X |
| DOI: | 10.1039/c5cc10451c |