A mild hydration of nitriles catalysed by copper(ii) acetateElectronic supplementary information (ESI) available: Experimental procedures and spectroscopic characterisation of all organic compounds. See DOI: 10.1039/c5cc08714g

A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N , N -diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wi...

Full description

Saved in:
Bibliographic Details
Main Authors Marcé, Patricia, Lynch, James, Blacker, A. John, Williams, Jonathan M. J
Format Journal Article
Published 14.01.2016
Online AccessGet full text

Cover

More Information
Summary:A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N , N -diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields. Amides are prepared in good yields from nitriles catalysed by a combination of copper acetate and N , N -diethylhydroxylamine
Bibliography:Electronic supplementary information (ESI) available: Experimental procedures and spectroscopic characterisation of all organic compounds. See DOI
10.1039/c5cc08714g
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc08714g