A new enzyme-free quadratic SERS signal amplification approach for circulating microRNA detection in human serumElectronic supplementary information (ESI) available: More experimental details, spectroscopic data and ethical statement as noted in text. See DOI: 10.1039/c5cc06549f

In this communication, we proposed a new enzyme-free quadratic SERS signal amplification approach for the ultrasensitive detection of circulating miRNA in human serum. Combined with miRNA-triggered hybridization chain reaction and Ag + -mediated cascade amplification, a limit of miRNA detection as l...

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Main Authors Zheng, Jing, Ma, Dandan, Shi, Muling, Bai, Junhui, Li, Yinhui, Yang, Jinfeng, Yang, Ronghua
Format Journal Article
LanguageEnglish
Published 29.10.2015
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Summary:In this communication, we proposed a new enzyme-free quadratic SERS signal amplification approach for the ultrasensitive detection of circulating miRNA in human serum. Combined with miRNA-triggered hybridization chain reaction and Ag + -mediated cascade amplification, a limit of miRNA detection as low as 0.3 fM could be achieved. More importantly, our method is suitable for the direct detection of circulating miRNAs in human serum collected from patients with different stages of chronic lymphocytic leukemia (CLL). In this communication, we proposed a new enzyme-free quadratic SERS signal amplification approach for the ultrasensitive detection of circulating miRNA in human serum.
Bibliography:10.1039/c5cc06549f
Electronic supplementary information (ESI) available: More experimental details, spectroscopic data and ethical statement as noted in text. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc06549f