Synthesis of diversely functionalised 2,2-disubstituted oxetanes: fragment motifs in new chemical spaceElectronic supplementary information (ESI) available: Experimental procedures, characterisation data, 1H and 13C NMR spectra; details of reaction optimisation and calculated molecular properties. See DOI: 10.1039/c5cc05740j
Di-, tri- and tetra-substituted oxetane derivatives with combinations of ester, amide, nitrile, aryl, sulfone and phosphonate substituents are prepared as fragments or building blocks for drug discovery. The synthesis of these novel oxetane functional groups, in new chemical space, is achieved via r...
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Main Authors | , , |
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Format | Journal Article |
Language | English |
Published |
08.10.2015
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Online Access | Get full text |
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