Synthesis of diversely functionalised 2,2-disubstituted oxetanes: fragment motifs in new chemical spaceElectronic supplementary information (ESI) available: Experimental procedures, characterisation data, 1H and 13C NMR spectra; details of reaction optimisation and calculated molecular properties. See DOI: 10.1039/c5cc05740j

Di-, tri- and tetra-substituted oxetane derivatives with combinations of ester, amide, nitrile, aryl, sulfone and phosphonate substituents are prepared as fragments or building blocks for drug discovery. The synthesis of these novel oxetane functional groups, in new chemical space, is achieved via r...

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Main Authors Davis, Owen A, Croft, Rosemary A, Bull, James A
Format Journal Article
LanguageEnglish
Published 08.10.2015
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Summary:Di-, tri- and tetra-substituted oxetane derivatives with combinations of ester, amide, nitrile, aryl, sulfone and phosphonate substituents are prepared as fragments or building blocks for drug discovery. The synthesis of these novel oxetane functional groups, in new chemical space, is achieved via rhodium-catalysed O-H insertion and C-C bond forming cyclisation. Novel oxetane motifs incorporating diverse functional groups on the ring are readily accessed by an O-H insertion/cyclisation strategy.
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C NMR spectra; details of reaction optimisation and calculated molecular properties. See DOI
Electronic supplementary information (ESI) available: Experimental procedures, characterisation data
H and
10.1039/c5cc05740j
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05740j