Cp2TiCl2-catalyzed cis-hydroalumination of propargylic amines with Red-Al: stereoselective synthesis of Z-configured allylic aminesElectronic supplementary information (ESI) available: Experimental details, NMR spectra of all compounds, and X-ray crystallography of 7a and 11. CCDC 1040902 (7a) and 1040903 (11). For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5cc00950b

• Main Authors: Sun, Renhong, Liu, Jun, Yang, Shuang, Chen, Ming, Sun, Ning, Chen, Haoyi, Xie, Xin, You, Xu, Li, Shi, Liu, Yuanhong
• Format: Journal Article
• Language: English
• Published: 26.03.2015

A titanium-catalyzed cis -hydroalumination of propargylic amines with Red-Al is described, which provides an efficient way to produce Z -configured allylic amines in good to excellent yields with high stereoselectivity and good regioselectivity. The hydride-bridged Al/Ti bimetallic species may act a...