Centrifugal partition chromatography: an efficient tool to access highly polar and unstable synthetic compounds on a large scaleElectronic supplementary information (ESI) available: Purification procedures, Kd determination, NMR spectra, microanalyses. See DOI: 10.1039/c4ra12141d

Centrifugal partition chromatography (CPC) is an efficient method adaptable for the purification of synthetic compounds with chemical value, significantly simplifying the reaction work-up. From Aucuba japonica Thunb., an abundant natural terpenoid, aucubin, was isolated. Its reduced derivatives and...

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Main Authors Markovi, Dean, Barboux, Cédric, Salle de Chou, Ysé, Bettach, Judith, Grougnet, Raphaël, Deguin, Brigitte
Format Journal Article
LanguageEnglish
Published 21.11.2014
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Summary:Centrifugal partition chromatography (CPC) is an efficient method adaptable for the purification of synthetic compounds with chemical value, significantly simplifying the reaction work-up. From Aucuba japonica Thunb., an abundant natural terpenoid, aucubin, was isolated. Its reduced derivatives and corresponding unstable aglucons were purified by CPC. The latter chiral synthons were obtained under protecting group free conditions using eco-friendly, non-chlorinated solvents and without silica gel. Centrifugal partition chromatography (CPC) is an efficient method adaptable for the purification of synthetic compounds with chemical value, significantly simplifying the reaction work-up.
Bibliography:Electronic supplementary information (ESI) available: Purification procedures, Kd determination, NMR spectra, microanalyses. See DOI
10.1039/c4ra12141d
ISSN:2046-2069
DOI:10.1039/c4ra12141d