Tryptophan: antioxidant or target of oxidative stress? A quantum chemistry elucidationElectronic supplementary information (ESI) available: Molecular graphics with main geometrical parameters and Cartesian coordinates of the compounds under study. Gibbs. See DOI: 10.1039/c4ra11635f

The Density Functional Theory was used to investigate oxidative stress related reactions of tryptophan in its free zwitterionic form. It was concluded that free tryptophan cannot be considered as an antioxidant, and that tryptophan residues in proteins are not especially good targets of oxidative st...

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Bibliographic Details
Main Authors Perez-Gonzalez, A, Muñoz-Rugeles, L, Alvarez-Idaboy, J. R
Format Journal Article
LanguageEnglish
Published 31.10.2014
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Summary:The Density Functional Theory was used to investigate oxidative stress related reactions of tryptophan in its free zwitterionic form. It was concluded that free tryptophan cannot be considered as an antioxidant, and that tryptophan residues in proteins are not especially good targets of oxidative stress. Its previously observed antioxidant abilities can then be attributed to tryptophan metabolites. Not a good antioxidant as a free molecule. Not a particularly easy target of common ROS in biological systems.
Bibliography:10.1039/c4ra11635f
Electronic supplementary information (ESI) available: Molecular graphics with main geometrical parameters and Cartesian coordinates of the compounds under study. Gibbs. See DOI
ISSN:2046-2069
DOI:10.1039/c4ra11635f