Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfonesDedicated to Richard Taylor who first taught me about vinyl sulphones and Weinreb amides, on the occasion of his 65th birthday.Electronic supplementary information (ESI) available: Copies of 1H and 13C NMR spectra. See DOI: 10.1039/c4ob01412j

An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the -lysine amino group. Members of this family demonstrated moderate to good efficacy as anti-trypanosomal agents and a fluorescent dansyl ( 19 )...

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Bibliographic Details
Main Authors Doherty, William, James, Jinju, Evans, Paul, Martin, Laura, Adler, Nikoletta, Nolan, Derek, Knox, Andrew
Format Journal Article
LanguageEnglish
Published 10.09.2014
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Summary:An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the -lysine amino group. Members of this family demonstrated moderate to good efficacy as anti-trypanosomal agents and a fluorescent dansyl ( 19 ) derivative was used to investigate subcellular localisation of the compound class. An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the -lysine amino group.
Bibliography:1
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Electronic supplementary information (ESI) available: Copies of
Dedicated to Richard Taylor who first taught me about vinyl sulphones and Weinreb amides, on the occasion of his 65
10.1039/c4ob01412j
C NMR spectra. See DOI
birthday.
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob01412j