Regioselective synthesis of 3,4,5-trisubstituted 2-aminofuransElectronic supplementary information (ESI) available: Synthesis, characterization of new compounds, computational details and crystallographic data of 7b and 8b. CCDC 949882 and 949883. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4ob01037j

Three series of methyl 5-substituted 2-aminofuran-4-keto-3-carboxylates have been prepared following a multicomponent reaction strategy by the addition of an isocyanide to 4-oxo-2-butynoate in the presence of an aldehyde. The cycloaddition regioselectivity is generally high (>95%) but decreases w...

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Bibliographic Details
Main Authors Huynh, Thi Ngoc Tram, Retailleau, Pascal, Denhez, Clément, Nguyen, Kim Phi Phung, Guillaume, Dom
Format Journal Article
LanguageEnglish
Published 24.06.2014
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Summary:Three series of methyl 5-substituted 2-aminofuran-4-keto-3-carboxylates have been prepared following a multicomponent reaction strategy by the addition of an isocyanide to 4-oxo-2-butynoate in the presence of an aldehyde. The cycloaddition regioselectivity is generally high (>95%) but decreases when an electron-rich substituent is located at the butynoate 4-position. Three series of methyl 5-substituted 2-aminofuran-4-keto-3-carboxylates have been prepared following a multicomponent reaction strategy by the addition of an isocyanide to 4-oxo-2-butynoate in the presence of an aldehyde.
Bibliography:CCDC
For ESI and crystallographic data in CIF or other electronic format see DOI
Electronic supplementary information (ESI) available: Synthesis, characterization of new compounds, computational details and crystallographic data of
and
8b
7b
949883
10.1039/c4ob01037j
949882
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob01037j