Design, synthesis and evaluation of new tricyclic endoperoxides as potential antiplasmodial agentsElectronic supplementary information (ESI) available. CCDC 997078 and 997079. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4ob00787e

Diastereoselective autoxidation allowed preparation of new tricyclic endoperoxides. These compounds and their methylated analogs were evaluated against the in vitro growth of Plasmodium falciparum , the malaria-causing parasite, showing moderate activities. However, hybrid molecules composed of the...

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Bibliographic Details
Main Authors Ruiz, Jérémy, Mallet-Ladeira, Sonia, Maynadier, Marjorie, Vial, Henri, André-Barrès, Christiane
Format Journal Article
LanguageEnglish
Published 24.06.2014
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Summary:Diastereoselective autoxidation allowed preparation of new tricyclic endoperoxides. These compounds and their methylated analogs were evaluated against the in vitro growth of Plasmodium falciparum , the malaria-causing parasite, showing moderate activities. However, hybrid molecules composed of the tricyclic peroxide moiety and 7-chloro-4-aminoquinoline were synthesized and displayed a marked increase in antiplasmodial activity. New tricyclic endoperoxides were obtained by a diastereoselective autoxidation; combined with 7-chloro-4-aminoquinoline, they display good antiplasmodial activities.
Bibliography:Electronic supplementary information (ESI) available. CCDC
For ESI and crystallographic data in CIF or other electronic format see DOI
10.1039/c4ob00787e
and
997079
997078
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob00787e