Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's diseaseElectronic supplementary information (ESI) available: Proton NMR, carbon NMR and HRMS spectra available. See DOI: 10.1039/c4ob00598h

In this paper we report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease. The compounds show excellent results as acetylcholinesterase inhibitors, being as active as the standard drug. All these comp...

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Main Authors Canto, Rômulo F. S, Barbosa, Flavio A. R, Nascimento, Vanessa, de Oliveira, Aldo S, Brighente, Inês M. C, Braga, Antonio Luiz
Format Journal Article
LanguageEnglish
Published 07.05.2014
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Summary:In this paper we report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease. The compounds show excellent results as acetylcholinesterase inhibitors, being as active as the standard drug. All these compounds also show very good antioxidant activity through different mechanisms of action. We report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease.
Bibliography:Electronic supplementary information (ESI) available: Proton NMR, carbon NMR and HRMS spectra available. See DOI
10.1039/c4ob00598h
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob00598h