The isolation and synthesis of neodolastane diterpenoidsThis article is dedicated to Prof. Reinhard Neier on the occasion of his birthday
Covering: 2000 to 2014 The neodolastane diterpenoids comprise a group of 44 compounds including guanacastepenes, heptemerones, plicatilisins, radianspenes, 2,15-epoxy-5,13-dihydroxyneodolast-3-en-14-one and sphaerostanol. These fungal and marine natural products are characterized by a tricyclic neod...
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| Main Authors | , , , , |
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| Format | Journal Article |
| Language | English |
| Published |
28.01.2015
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| Online Access | Get full text |
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| Summary: | Covering: 2000 to 2014
The neodolastane diterpenoids comprise a group of 44 compounds including guanacastepenes, heptemerones, plicatilisins, radianspenes, 2,15-epoxy-5,13-dihydroxyneodolast-3-en-14-one and sphaerostanol. These fungal and marine natural products are characterized by a tricyclic neodolastane skeleton that consists of fused five-, seven- and six-membered rings. Their reported antibiotic activities against antibiotic-resistant bacteria together with strong antifungal and anticancer activities and their novel structures render these compounds interesting synthetic targets. The aim of this account is to summarise the progress in the isolation, characterisation and synthesis of these diterpenoids as well as to review their biogenetic origins and diverse biological activities since their discovery in 2000.
This account summarises the progress in isolation, characterisation and synthesis of diterpenoids sharing a tricyclic neodolastane skeleton as well as their biogenetic origin and diverse biological activities. |
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| Bibliography: | 2 chemistry. This article is dedicated to Prof. Reinhard Neier on the occasion of his birthday. François-Hugues Porée was born in Paris in 1976. During his education, he focused on pharmaceutical studies and completed his formation in 2003 with a PhD in organic chemistry at the Université de Cergy Pontoise under the guidance of Dr Pancrazi and Prof. Ardisson (Dina Surdin award of the French Chemical Society). Then, he joined the laboratory of Prof. Fürstner (Mülheim/Ruhr) and focused on organocatalysis. Since 2005, he has been an assistant professor in the laboratory of Pharmacognosy at Université Paris Descartes. His interests cover the field of natural product pharmaceuticals with an emphasis on the synthesis of bioactive compounds. M ris Turks obtained his M.Sc. degree from Riga Technical University (RTU) in 2000. He earned his doctoral degree in synthetic organic chemistry in 2005 from the Swiss Federal Institute of Technology Lausanne (EPFL) under the supervision of Professor Pierre Vogel. In 2006 he worked as a SNSF Postdoctoral Fellow with Professor Barry M. Trost at Stanford University. Currently, M ris Turks is a Full Professor at the Faculty of Material Science and Applied Chemistry, RTU. His research interests are in the area of carbohydrate, nucleoside and natural product chemistry, functionalized heterocycles, and the applications of liquid sulfur dioxide in organic synthesis. Maria Kolympadi graduated with a M.Sc. degree from the University of Athens, Greece. She pursued her PhD studies in organic chemistry with Prof. Pierre Vogel at the Swiss Federal Institute of Technology in Lausanne (EPFL), and postdoctoral studies with Prof. Reinhard Neier at the University of Neuchâtel, Switzerland. She is currently on a short-term assignment at the University Paris Descartes, France. Her research activities consider semi-synthetic and synthetic approaches to terpenoid natural products, carbohydrate mimics and heterocyclic derivatives. She joined the group of Prof. Michel Koch at the University Paris Descartes where she became Assistant Professor of pharmacognosy in 1995 and subsequently Full Professor in 2006. Her research interests focus on natural products and the valorization of terpenes in organic synthesis. Brigitte Deguin received her PhD in organic chemistry in 1989 from the University Pierre and Marie Curie (Paris) working at the Institute Curie with Dr Claude Monneret in the field of anthracyclinones. She spent several years at the University of Lausanne as a postdoctoral collaborator with Prof. Pierre Vogel to study the hetero Diels-Alder addition of SO Dean Markovi studied at the University of Zagreb and obtained his PhD degree with Prof. Pierre Vogel at EPF-Lausanne (2005). After post-doctoral appointments with Prof. John Hartwig at Yale University (2006) and UIUC Urbana-Champaign (2007) as an SNSF and F. Hoffmann-La Roche fellow, he held a scientific collaborator position at EPFL (2008-2011). He finished his habilitation at the University Paris Descartes (2012). He has been a visiting professor at the University of Rijeka (2010). His research interests include the chemistry of natural products, new catalytic methodologies, mechanistic studies and physical organic aspects of metal catalyzed reactions and SO |
| ISSN: | 0265-0568 1460-4752 |
| DOI: | 10.1039/c4np00077c |