Relating Caco-2 permeability to molecular properties using block relevance analysisElectronic supplementary information (ESI) available: Full table of measured Caco-2 permeability used in the modelling. See DOI: 10.1039/c4md00470a

Here we describe a new approach for facilitating a mechanistic understanding of high throughput Caco-2 permeability data. A large, uniform set of permeability data is reported, generated under two pH conditions. It was found that these data could be successfully modelled, and that a mechanistic unde...

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Bibliographic Details
Main Authors Potter, T, Ermondi, G, Newbury, G, Caron, G
Format Journal Article
LanguageEnglish
Published 10.04.2015
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Summary:Here we describe a new approach for facilitating a mechanistic understanding of high throughput Caco-2 permeability data. A large, uniform set of permeability data is reported, generated under two pH conditions. It was found that these data could be successfully modelled, and that a mechanistic understanding of apparent permeability could be gained. New insights into physicochemical drivers for Caco-2 permeability have been gained using a modelling technique known as block relevance analysis.
Bibliography:10.1039/c4md00470a
Electronic supplementary information (ESI) available: Full table of measured Caco-2 permeability used in the modelling. See DOI
ISSN:2040-2503
2040-2511
DOI:10.1039/c4md00470a