Probing solvent effects on mixed aggregates associating a chiral lithium amide and n-BuLi by NMR: from structure to reactivityElectronic supplementary information (ESI) available: All monodimensional and bidimensional NMR spectra. See DOI: 10.1039/c4dt01156b

An NMR study of a 1 : 1 mixture of a chiral lithium amide ( 4a ) and n -BuLi shows that depending on the solvent employed (Et 2 O or THF) a mixed aggregate can form in proportions that are directly related to the ees measured during the enantioselective alkylation of o -tolualdehyde by these same sp...

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Bibliographic Details
Main Authors Barozzino-Consiglio, Gabriella, Rouen, Mathieu, Oulyadi, Hassan, Harrison-Marchand, Anne, Maddaluno, Jacques
Format Journal Article
LanguageEnglish
Published 10.09.2014
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Summary:An NMR study of a 1 : 1 mixture of a chiral lithium amide ( 4a ) and n -BuLi shows that depending on the solvent employed (Et 2 O or THF) a mixed aggregate can form in proportions that are directly related to the ees measured during the enantioselective alkylation of o -tolualdehyde by these same species. NMR shows a direct correlation between the concentration of a chiral lithium amide/ n -BuLi complex and ees of a test reaction.
Bibliography:Electronic supplementary information (ESI) available: All monodimensional and bidimensional NMR spectra. See DOI
10.1039/c4dt01156b
ISSN:1477-9226
1477-9234
DOI:10.1039/c4dt01156b