A concise route to the highly-functionalized azetidine precursor: the enantioselective synthesis of penaresidin BElectronic supplementary information (ESI) available. See DOI: 10.1039/c4cc09904d

An efficient and high-yielding synthesis of penaresidin B is disclosed herein. The concise 8-step synthesis of azetidine aldehyde was devised by incorporating our novel strategy for ready access to 3-amino-2,3-dideoxysugars via regio- and stereoselective tandem hydroamination/glycosylation of glycal...

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Bibliographic Details
Main Authors Ding, Feiqing, William, Ronny, Kock, Si Min, Leow, Min Li, Liu, Xue-Wei
Format Journal Article
LanguageEnglish
Published 03.03.2015
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Summary:An efficient and high-yielding synthesis of penaresidin B is disclosed herein. The concise 8-step synthesis of azetidine aldehyde was devised by incorporating our novel strategy for ready access to 3-amino-2,3-dideoxysugars via regio- and stereoselective tandem hydroamination/glycosylation of glycal as the key step. An efficient, high-yielding and scalable synthesis of penaresidin B is achieved, in which the highly functionalized azetidine precursor is constructed and stereoselectively from glycal.
Bibliography:10.1039/c4cc09904d
Electronic supplementary information (ESI) available. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc09904d