Cucurbit[8]uril templated supramolecular ring structure formation and protein assembly modulationElectronic supplementary information (ESI) available: Experimental section, 1H-NMR, ITC, reaction equilibria, DOSY-NMR, SEC, QTOF-MS, MALDI-TOF MS, FGG-mYFP sequence, fluorescence anisotropy. See DOI: 10.1039/c4cc08917k

The interplay of Phe-Gly-Gly (FGG)-tagged proteins and bivalent FGG-tagged penta(ethylene glycol) as guest molecules with cucurbit[8]uril (Q8) hosts is studied to modulate the supramolecular assembly process. Ring structure formation of the bivalent guest molecule with Q8 leads to enhanced binding p...

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Bibliographic Details
Main Authors Ramaekers, Mellany, Wijnands, Sjors P. W, van Dongen, Joost L. J, Brunsveld, Luc, Dankers, Patricia Y. W
Format Journal Article
LanguageEnglish
Published 05.02.2015
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Summary:The interplay of Phe-Gly-Gly (FGG)-tagged proteins and bivalent FGG-tagged penta(ethylene glycol) as guest molecules with cucurbit[8]uril (Q8) hosts is studied to modulate the supramolecular assembly process. Ring structure formation of the bivalent guest molecule with Q8 leads to enhanced binding properties and efficient inhibition of protein assemblies. A multicomponent host-guest system composed of synthetic small molecules as guests in a supramolecular host shows efficient protein dimerization inhibition.
Bibliography:1
10.1039/c4cc08917k
H-NMR, ITC, reaction equilibria, DOSY-NMR, SEC, QTOF-MS, MALDI-TOF MS, FGG-mYFP sequence, fluorescence anisotropy. See DOI
Electronic supplementary information (ESI) available: Experimental section
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc08917k