A highly selective sulfinate ester probe for thiol bioimagingElectronic supplementary information (ESI) available: Preparative procedures, characterization data, assay protocols and spectral data. See DOI: 10.1039/c4cc05462h

We describe here hitherto unexplored chemistry of the sulfinate ester functional group as being highly selective towards nucleophilic substitution by thiols at physiological pH. Using this cleavable trigger, an optical thiol probe that is suitable for thiol bioimaging has been developed. The sulfina...

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Bibliographic Details
Main Authors Malwal, Satish R, Labade, Ajay, Andhalkar, Abhijeet S, Sengupta, Kundan, Chakrapani, Harinath
Format Journal Article
LanguageEnglish
Published 04.09.2014
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Summary:We describe here hitherto unexplored chemistry of the sulfinate ester functional group as being highly selective towards nucleophilic substitution by thiols at physiological pH. Using this cleavable trigger, an optical thiol probe that is suitable for thiol bioimaging has been developed. The sulfinate ester functional group is found to be highly selective to cleavage by a thiol.
Bibliography:10.1039/c4cc05462h
Electronic supplementary information (ESI) available: Preparative procedures, characterization data, assay protocols and spectral data. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc05462h