A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reactionElectronic supplementary information (ESI) available: Copies of spectra of all compounds. See DOI: 10.1039/c4cc01791a

The InCl 3 -catalyzed sequential multicomponent reaction between 2-furfurylamine, β-dicarbonyl compounds and α,β-unsaturated aldehydes in ethanol, followed by microwave irradiation in solvent-free conditions, afforded good to excellent yields of highly substituted pyridines, with loss of a 2-furylme...

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Main Authors Raja, V. P. Alex, Tenti, Giammarco, Perumal, Subbu, Menéndez, J. Carlos
Format Journal Article
LanguageEnglish
Published 18.09.2014
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Summary:The InCl 3 -catalyzed sequential multicomponent reaction between 2-furfurylamine, β-dicarbonyl compounds and α,β-unsaturated aldehydes in ethanol, followed by microwave irradiation in solvent-free conditions, afforded good to excellent yields of highly substituted pyridines, with loss of a 2-furylmethyl side chain. The method was also adapted to the synthesis of quinolones, isoquinolines, phenanthridines and more complex fused pyridine systems. Pyridines and fused pyridines are accessible by a combination of a Lewis acid-catalyzed multicomponent reaction and aromatization involving loss of a 2-furylmethyl chain.
Bibliography:Electronic supplementary information (ESI) available: Copies of spectra of all compounds. See DOI
10.1039/c4cc01791a
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc01791a