Synthesis of alkylcarbonate analogs of O-acetyl-ADP-riboseElectronic supplementary information (ESI) available: Copies of 1H-NMR and 13C-NMR spectra of all new compounds. See DOI: 10.1039/c3ob41016a

The non-hydrolyzable alkylcarbonate analogs of O -acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1. Alkylcarb...

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Main Authors Dvorakova, Marcela, Nencka, Radim, Dejmek, Milan, Zbornikova, Eva, Brezinova, Anna, Pribylova, Marie, Pohl, Radek, Migaud, Marie E, Vanek, Tomas
Format Journal Article
LanguageEnglish
Published 07.08.2013
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Summary:The non-hydrolyzable alkylcarbonate analogs of O -acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1. Alkylcarbonate analogs of O -acetyl-ADP-ribose were prepared using a ball mill and assessed for their ability to inhibit SIRT1.
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C-NMR spectra of all new compounds. See DOI
H-NMR and
Electronic supplementary information (ESI) available: Copies of
10.1039/c3ob41016a
ISSN:1477-0520
1477-0539
DOI:10.1039/c3ob41016a