Efficient microwave-assisted synthetic protocols and in silico behaviour prediction of per-substituted β-cyclodextrinsElectronic supplementary information (ESI) available: Spectra 1H, 13C, 2D HMQC NMR, MS of all compounds. See DOI: 10.1039/c3ob40909k

Selective per -substituted cyclodextrin design enables the carrier's physicochemical and binding properties to be tailored and can even modify some biological native structure effects. We herein report a number of highly efficient microwave-assisted synthetic protocols for the preparation of se...

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Bibliographic Details
Main Authors Martina, K, Cravotto, G, Caporaso, M, Rinaldi, L, Villalonga-Barber, C, Ermondi, G
Format Journal Article
LanguageEnglish
Published 31.07.2013
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Summary:Selective per -substituted cyclodextrin design enables the carrier's physicochemical and binding properties to be tailored and can even modify some biological native structure effects. We herein report a number of highly efficient microwave-assisted synthetic protocols for the preparation of several amino, ureido and thioureido per -substituted β-cyclodextrin derivatives. A rapid parallel synthetic approach has given a set of 14 different CD derivatives. Our strategy is supported by computational analyses which were used to estimate the physicochemical behaviour of per -substituted derivatives and to tailor suitable substituents. Highly efficient microwave-assisted synthetic decoration of per -substituted β-cyclodextrins supported by computational analyses.
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C, 2D HMQC NMR, MS of all compounds. See DOI
H
10.1039/c3ob40909k
Electronic supplementary information (ESI) available: Spectra
ISSN:1477-0520
1477-0539
DOI:10.1039/c3ob40909k