Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(ii) complexes of heterosubstituted cyclensElectronic supplementary information (ESI) available: Experimental details and analytical data. CCDC 911568 and 911569. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3dt32857k

The Cu( ii ) complexes of cyclen and two of its heterosubstituted analogues were shown to be efficient oxidative DNA cleavers. The reactivity strongly depends on the heteroatom inserted into the macrocycle (O > S > N). Heteroatom substitution in Cu( ii ) cyclen complexes leads to a considerabl...

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Bibliographic Details
Main Authors Hormann, Jan, Perera, Chrischani, Deibel, Naina, Lentz, Dieter, Sarkar, Biprajit, Kulak, Nora
Format Journal Article
LanguageEnglish
Published 05.03.2013
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Summary:The Cu( ii ) complexes of cyclen and two of its heterosubstituted analogues were shown to be efficient oxidative DNA cleavers. The reactivity strongly depends on the heteroatom inserted into the macrocycle (O > S > N). Heteroatom substitution in Cu( ii ) cyclen complexes leads to a considerable increase of oxidative DNA cleavage activity.
Bibliography:For ESI and crystallographic data in CIF or other electronic format see DOI
911569
10.1039/c3dt32857k
911568
and
Electronic supplementary information (ESI) available: Experimental details and analytical data. CCDC
ISSN:1477-9226
1477-9234
DOI:10.1039/c3dt32857k