An intracellular buildup reaction of active siRNA species from short RNA fragmentsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3cc47529h

Here we report a new strategy for the buildup reaction of active siRNA species from short RNA fragments in living cells using a chemical ligation reaction. This strategy could decrease undesired immune responses and provide more latitude for RNAi technology in the design and concentration of introdu...

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Bibliographic Details
Main Authors Maruyama, Hideto, Nakashima, Yuko, Shuto, Satoshi, Matsuda, Akira, Ito, Yoshihiro, Abe, Hiroshi
Format Journal Article
LanguageEnglish
Published 09.01.2014
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Summary:Here we report a new strategy for the buildup reaction of active siRNA species from short RNA fragments in living cells using a chemical ligation reaction. This strategy could decrease undesired immune responses and provide more latitude for RNAi technology in the design and concentration of introduced RNA compared to traditional siRNA methods. An intracellular buildup reaction of active siRNA species from short RNA fragments provided a potent RNAi effect without stimulation of immune response.
Bibliography:10.1039/c3cc47529h
Electronic supplementary information (ESI) available. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc47529h