AlCl3-mediated hydroarylationheteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interestElectronic supplementary information (ESI) available: Experimental procedures, spectral data for all new compounds, results of in vitro/in vivo and docking study. See DOI: 10.1039/c3cc42840k

An unprecedented AlCl 3 -mediated method has been developed involving aromatic CH bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins. Novel 2-viny...

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Main Authors Nakhi, Ali, Archana, Sivakumar, Seerapu, Guru Pavan Kumar, Chennubhotla, Keerthana Sarma, Kumar, Kummari Lalith, Kulkarni, Pushkar, Haldar, Devyani, Pal, Manojit
Format Journal Article
LanguageEnglish
Published 18.06.2013
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Summary:An unprecedented AlCl 3 -mediated method has been developed involving aromatic CH bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins. Novel 2-vinyl-3-arylquinoxalines are synthesized via an AlCl 3 -mediated hydroarylationheteroarylation reaction in a single pot.
Bibliography:and docking study. See DOI
10.1039/c3cc42840k
in vitro
in vivo
Electronic supplementary information (ESI) available: Experimental procedures, spectral data for all new compounds, results of
/
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc42840k