A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ionElectronic supplementary information (ESI) available: Details of experimental procedures and additional experimental data. See DOI: 10.1039/c3cc39067e

The dinucleating ligand L (1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol) combined with metal ions efficiently cleaves DNA when M : L is 1 : 1 (M = Co( ii ) or Fe( iii )) at pH 5.5-7.0, with free L being more active at acidic pH than when bound to Zn( ii ), Cu( ii ) or Ni( ii ) at neutral pH. The...

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Bibliographic Details
Main Authors Hernández-Gil, Javier, Ferrer, Sacramento, Salvador, Elena, Calvo, Javier, Garcia-España, Enrique, Mareque-Rivas, Juan C
Format Journal Article
LanguageEnglish
Published 04.04.2013
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Summary:The dinucleating ligand L (1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol) combined with metal ions efficiently cleaves DNA when M : L is 1 : 1 (M = Co( ii ) or Fe( iii )) at pH 5.5-7.0, with free L being more active at acidic pH than when bound to Zn( ii ), Cu( ii ) or Ni( ii ) at neutral pH. The dinucleating ligand L (1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol) combined with metal ions efficiently cleaves DNA when M : L is 1 : 1 (M = Co( ii ) or Fe( iii )) at pH 5.5-7.0, with free L being more active at acidic pH than when bound to Zn( ii ), Cu( ii ) or Ni( ii ) at neutral pH.
Bibliography:Electronic supplementary information (ESI) available: Details of experimental procedures and additional experimental data. See DOI
10.1039/c3cc39067e
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc39067e