Efficient iodine catalyzed three components domino reaction for the synthesis of 1-((phenylthio)(phenyl)methyl)pyrrolidin-2-one derivatives possessing anticancer activitiesElectronic supplementary information (ESI) available: Experimental procedure, full compound characterization, 1H NMR, 13C NMR and HPLC. See DOI: 10.1039/c2ob25530h

A simple and efficient three components domino reaction of γ-butyrolactam (2-pyrrolidinone), aromatic aldehyde and substituted thiophenol catalyzed by elemental iodine resulted in the formation of 1-((phenylthio)(phenyl)methyl)pyrrolidin-2-one derivatives. The stability of the synthesized analogues...

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Main Authors Ramachandran, Gunasekar, Karthikeyan, Natesan S, Giridharan, Periyasamy, Sathiyanarayanan, Kulathu I
Format Journal Article
LanguageEnglish
Published 27.06.2012
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Summary:A simple and efficient three components domino reaction of γ-butyrolactam (2-pyrrolidinone), aromatic aldehyde and substituted thiophenol catalyzed by elemental iodine resulted in the formation of 1-((phenylthio)(phenyl)methyl)pyrrolidin-2-one derivatives. The stability of the synthesized analogues was evaluated in stimulated gastric fluid (SGF) and bovine serum albumin (BSA). In vitro anticancer activity was investigated in the low micromolar range and a few analogues were found to possess good activity. This current protocol provides several advantages like shorter reaction time, excellent yield and convenient work-up. A three components domino reaction of γ-butyrolactam, benzaldehyde and thiophenol catalyzed by elemental iodine results in anticancer agents.
Bibliography:C NMR and HPLC. See DOI
Electronic supplementary information (ESI) available: Experimental procedure, full compound characterization
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13
10.1039/c2ob25530h
H NMR
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob25530h