Developing novel C-4 analogues of pyrrole-based antitubulin agents: weak but critical hydrogen bonding in the colchicine siteElectronic supplementary information (ESI) available: Experimental details for the synthesis and characterization of reported compounds, procedures for the assays and additional information on the computational methods utilized. See DOI: 10.1039/c2md20320k

The synthesis, biological evaluation and molecular modeling of a series of pyrrole compounds related to 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1 H -pyrrole-2-carboxylic acid that evaluates and optimizes C-4 substituents are reported. The key factor for microtubule depolymerization activity appears to b...

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Main Authors Da, Chenxiao, Telang, Nakul, Hall, Kayleigh, Kluball, Emily, Barelli, Peter, Finzel, Kara, Jia, Xin, Gupton, John T, Mooberry, Susan L, Kellogg, Glen E
Format Journal Article
LanguageEnglish
Published 30.01.2013
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Summary:The synthesis, biological evaluation and molecular modeling of a series of pyrrole compounds related to 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1 H -pyrrole-2-carboxylic acid that evaluates and optimizes C-4 substituents are reported. The key factor for microtubule depolymerization activity appears to be the presence of an appropriately positioned acceptor for Cys241β in the otherwise hydrophobic subpocket A. SAR and detailed structural analysis of tubulin's colchicine site reveals that H-bond donation from Cys241β is crucial in the otherwise hydrophobic subpocket A.
Bibliography:10.1039/c2md20320k
Electronic supplementary information (ESI) available: Experimental details for the synthesis and characterization of reported compounds, procedures for the assays and additional information on the computational methods utilized. See DOI
ISSN:2040-2503
2040-2511
DOI:10.1039/c2md20320k