Synthesis and biological evaluation of 4-chlorocolchicine derivatives as potent anticancer agents with broad effective dosage rangesElectronic supplementary information (ESI) available: Synthetic procedures and characterization data of all compounds, as well as methodology used in cytotoxicity evaluation, antitumor experiments, metabolic stability experiments, and docking simulations. See DOI: 10.1039/c2md20250f

4-Chlorocolchicine derivatives were synthesized with a view of developing new anticancer agents. The derivatives were examined for their potent activities and effective dosage ranges in mice, as well as favorable metabolic stabilities. As a result, derivatives 37 and 40 , bearing an α-hydroxyalkanoy...

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Main Authors Nishiyama, Hiroyuki, Ono, Masahiro, Sugimoto, Takuya, Sasai, Toshio, Asakawa, Naoyuki, Yaegashi, Takashi, Nagaoka, Masato, Matsuzaki, Takeshi, Kogure, Noriyuki, Kitajima, Mariko, Takayama, Hiromitsu
Format Journal Article
LanguageEnglish
Published 21.11.2012
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Summary:4-Chlorocolchicine derivatives were synthesized with a view of developing new anticancer agents. The derivatives were examined for their potent activities and effective dosage ranges in mice, as well as favorable metabolic stabilities. As a result, derivatives 37 and 40 , bearing an α-hydroxyalkanoyl group on the C-7 amino function, were revealed to exhibit potent activities with broad effective dosage ranges. 4-Chlorocolchicine derivatives bearing an α-hydroxyalkanoyl group on the C-7 amino function showed high potencies as anticancer agents.
Bibliography:Electronic supplementary information (ESI) available: Synthetic procedures and characterization data of all compounds, as well as methodology used in cytotoxicity evaluation, antitumor experiments, metabolic stability experiments, and docking simulations. See DOI
10.1039/c2md20250f
ISSN:2040-2503
2040-2511
DOI:10.1039/c2md20250f