Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer's diseaseElectronic supplementary information (ESI) available: Experimental details for synthesis and characterization of [18F]1, 1-4, 4-halo-hydroxyquinoline derivatives, as well as in vitro, immunohistochemistry, and imaging studies. See DOI: 10.1039/c2md20075a

Benzyloxy-2-chloroquinoline was reacted with fluorine-18 labelled potassium cryptand fluoride, followed by catalytic hydrogenation to prepare [ 18 F]2-fluoroquinolin-8-ol in high radiochemical yields (30%; uncorrected and relative to [ 18 F]-fluoride), specific activities (>1 Ci μmol −1 ) and rad...

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Main Authors Vasdev, Neil, Cao, Pengpeng, van Oosten, Erik M, Wilson, Alan A, Houle, Sylvain, Hao, Guiyang, Sun, Xiankai, Slavine, Nikolai, Alhasan, Mustafa, Antich, Peter P, Bonte, Frederick J, Kulkarni, Padmakar
Format Journal Article
LanguageEnglish
Published 26.09.2012
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Summary:Benzyloxy-2-chloroquinoline was reacted with fluorine-18 labelled potassium cryptand fluoride, followed by catalytic hydrogenation to prepare [ 18 F]2-fluoroquinolin-8-ol in high radiochemical yields (30%; uncorrected and relative to [ 18 F]-fluoride), specific activities (>1 Ci μmol −1 ) and radiochemical purities (>99%) within 70 min; PET-CT imaging with this new radiotracer in double transgenic mice shows excellent promise for imaging Alzheimer's disease. PET-CT imaging with [ 18 F]2-fluoroquinolin-8-ol in double transgenic mice shows excellent promise for imaging Alzheimer's disease.
Bibliography:immunohistochemistry, and imaging studies. See DOI
1
10.1039/c2md20075a
F
in vitro
18
1-4
4-halo-hydroxyquinoline derivatives, as well as
,
Electronic supplementary information (ESI) available: Experimental details for synthesis and characterization of
ISSN:2040-2503
2040-2511
DOI:10.1039/c2md20075a