Aminoglycoside antibiotics bind to the influenza A virus RNA promoterElectronic supplementary information (ESI) available. See DOI: 10.1039/c2mb25333j

Aminoglycosides bind to the influenza A virus promoter (vRNA) at submicromolar concentration. The complex structure between the vRNA and neomycin illustrates that binding of neomycin causes a conformational change which would affect further transcription processes. Thus, aminoglycosides represent le...

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Main Authors Kim, Henna, Lee, Mi-Kyung, Ko, Junsang, Park, Chin-Ju, Kim, Meehyein, Jeong, Yujeong, Hong, Sungwoo, Varani, Gabriele, Choi, Byong-Seok
Format Journal Article
LanguageEnglish
Published 02.10.2012
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Summary:Aminoglycosides bind to the influenza A virus promoter (vRNA) at submicromolar concentration. The complex structure between the vRNA and neomycin illustrates that binding of neomycin causes a conformational change which would affect further transcription processes. Thus, aminoglycosides represent lead compounds for the discovery of antiviral therapeutics against influenza A virus. Aminoglycosides bind to the influenza A virus promoter (vRNA) and cause a conformational change which is anticipated to prevent influenza A virus RdRp binding.
Bibliography:10.1039/c2mb25333j
Electronic supplementary information (ESI) available. See DOI
ISSN:1742-206X
1742-2051
DOI:10.1039/c2mb25333j